The rs8180086, rs3732765, rs10935840, and rs11708767 SNPs of P2RY12, can alter airway hyperresponsiveness in asthmatics exposed to a 1.85 μg/g concentration of house dust mite, whereas the rs7615865 and rs149197 SNPs modified bronchodilator reversibility. The gene discussed is P2RY12; the disease is airway hyperresponsiveness.