HDM exposure at 10 μg/g demonstrated similar results, in where the rs3732765, rs10935840, and rs1170876 SNPs demonstrated altered airway hyperresponsiveness, and the rs10935844 and rs8180086 SNPs alter FVC in an asthmatic cohort, thereby providing evidence for a gene-environment interaction between P2RY12 variants and HDM [145]. The gene discussed is P2RY12; the disease is airway hyperresponsiveness.