E2F4 and pancreatic neoplasm: MiR-29a is also considered an oncogenic miRNA, which is related to the migratory and invasive behavior of PDAC, while miR-17-5p (part of the miR-17-92 cluster) interferes with the cell cycle and promotes the proliferation of pancreatic cancer cells by disrupting retinoblastoma-like protein 2 (RBL2)/E2F Transcription Factor 4 (E2F4)-repressing complexes [99,100].