MiR-340 overexpression is closely associated with the regulation of Bicaudal-D2 (BICD2), leading to the inhibition of pancreatic malignant cell growth and progression, implying the anti-neoplastic potential of miR-340/BICD2 axis [72].MiRNA-506 constitutes another miRNA that acts as tumor suppressor and significantly reduces the PDAC progression, although this is achieved when it is overexpressed [73]. Here, BICD2 is linked to neoplasm.