In the same experimental group at different ages: the relative expression of BMP-2 mRNA in the 30-day-old leg cartilage tissue of the CHF group and BPs group was higher than that of the 60-day-old, and the CHF-M group was significantly higher at 30 days than at 60 days (p < 0.05). The gene discussed is BMP2; the disease is Bartsocas-Papas syndrome 1.