In the same treatment group at different ages: the OPG content in the serum of all treatment groups at 30 days of age was higher than that at 60 days of age, and the CHF-M group BPs-H, and BPs-M group 30-day-old serum OPG content was significantly higher than 60-day-old (p < 0.05). The gene discussed is TNFRSF11B; the disease is congestive heart failure.