Although our study was based on the bioinformatic analysis, we claim that the ten immune-related genes (BIRC5, CDK4, DCK, HSPA4, HSP90AA1, PSMD2, IL1RN, PGF, SPP1, and STC2) are novel targets for antitumor immunity, which may enrich the field for treating HCC patients. The gene discussed is SPP1; the disease is hepatocellular carcinoma.