At the beginning of the study, 98 patients presented evidence of depression, and this condition was significantly associated with CNR1 polymorphism, rs1049353 (chi squared 6.12, p = 0.013), with a larger proportion of women (chi 5.4; p = 0.02; odds ratio 1.8 CL 1.1–3.1). The gene discussed is CNR1; the disease is major depressive disorder.