UBE2C and laryngotracheoesophageal cleft: In addition, based on our previous study [39], the analysis of tumor tissue single-cell transcriptome data showed that the expression of UBE2C has a significant up-regulation trend in cancer cell clusters (CS), such as CS4 of CRC, CS2 of LC, CS4 of OV, CS3 of PDAC, and CS5 of SCC (Figure S4).