Previous studies have revealed that E2F1 can induce cell metastasis by inducing chemoresistance, angiogenesis, secondary site extravasation, and EMT [63,64,65,66,67,68,69] This study found that E2F1 was significantly highly expressed in 20 cancers, and it was significantly related to the poor prognosis in patients of 9 different cancers. Here, E2F1 is linked to cancer.