In addition, based on our previous study [39], the analysis of tumor tissue single-cell transcriptome data showed that the expression of UBE2C has a significant up-regulation trend in cancer cell clusters (CS), such as CS4 of CRC, CS2 of LC, CS4 of OV, CS3 of PDAC, and CS5 of SCC (Figure S4). The gene discussed is UBE2C; the disease is neoplasm.