As a key downstream gene of KAT2A and E2F1, we also found that UBE2C significantly inhibited the proliferation of the liver cancer cell line, HepG2, and pancreatic cancer cell line, BxPC3, through a CCK-8 assay (Figure S5), which suggested that UBE2C plays a critical role in pan-cancer. Here, E2F1 is linked to familial pancreatic carcinoma.