Chondroitin sulfate proteoglycan 4 (CSPG4) [32,33] is a surface type I transmembrane core proteoglycan that is important in cell survival, migration, and angiogenesis and has been associated with the progression and metastasis of tumors, such as gliomas and soft tissue sarcomas. The gene discussed is CSPG4; the disease is central nervous system cancer.