FOXP1 and Intellectual disability: The FOXP1 gene, which was hypomethylated in FXSA, compared to TD, encodes for a transcription factor important for early brain development and, interestingly, variants, deletions, missense mutations FOXP1 are causative for severe forms of ASD, often comorbid with intellectual disability, language deficits, and congenital anomalies, including mild dysmorphic features, and brain, cardiac, and urogenital abnormalities [64].