NF2 and fragile X syndrome: Further, the expression of NF2 mRNA was significantly lower in participants with ASD (n = 16) than the expression in TD children (n = 8, p = 0.045) and children with FXS-ASD (n = 16, p = 0.012), which also agreed with the hypermethylation status of CpG sites within the gene observed in children with ASD compared to TD.