In similar, MTX, Etoposide, Fulvestrant, and Resveratrol could suppress the expression of FOXD1, FOXA1, FOXM1, and FOXP1, respectively, which exhibited oncogenic potential in LGG, PRCA/breast cancer, LUAD/LUSC, and PAAD. The gene discussed is FOXA1; the disease is pancreatic adenocarcinoma.