Most importantly, FOX family genes, such as FOXA1, FOXC2, FOXE1, FOXF1, FOXM1, FOXO1, FOXO3, FOXO4, FOXO6, FOXP1, FOXP3, FOXQ1, and FOXR1, have been documented to play key roles in cancer by acting as tumor suppressors and/or oncogenes genes [3,4,6,7]. The gene discussed is FOXO3; the disease is cancer.