On the one hand, based on the intersection of FOX genes that are differentially expressed in more than 30 cancers and respond to more than 30 chemotherapeutics simultaneously, the current study has identified six FOX genes, such as FOXJ3, FOXK2, FOXN2, FOXN3, FOXO1, and FOXO3, which play an important role in the development of a wide range of cancers and may share similar pathogenic mechanisms. This evidence concerns the gene FOXO1 and cancer.