Among the 43 FOX genes, we found that FOXA2, FOXC1, FOXD1, FOXE1, FOXF1, FOXF2, FOXG1, FOXJ2, FOXJ3, FOXM1, FOXN2, FOXN3, FOXO3, FOXO4, and FOXP3 were differentially expressed in a large number of leukemias with significant changes, suggesting that these genes play an important role in the pathogenesis of leukemia (Figure 1A). The gene discussed is FOXO3; the disease is leukemia.