FOXO1 and cancer: Most importantly, FOX family genes, such as FOXA1, FOXC2, FOXE1, FOXF1, FOXM1, FOXO1, FOXO3, FOXO4, FOXO6, FOXP1, FOXP3, FOXQ1, and FOXR1, have been documented to play key roles in cancer by acting as tumor suppressors and/or oncogenes genes [3,4,6,7].