Among all the regulated FOX genes in leukemia, the high expression of FOXO4 and FOXP3 in multiple leukemia types and their correlation, as well as the prognostic value of FOXP3 in AML, suggest the importance of FOXO4 and FOXP3 in leukemia, especially AML, and the potential of their combination as biomarkers for AML diagnosis and drug sensitivity. This evidence concerns the gene FOXP3 and leukemia.