We found that almost the majority of FOX genes differentially expressed in multiple cancers (>30) showed sensitivity to multiple chemotherapeutic agents (>30), suggesting that these FOX genes, including FOXJ3, FOXK2, FOXN2, FOXN3, FOXO1, and FOXO3, play an important role in the initiation and progression of cancers and could serve as important therapeutic targets for cancers (Figure 8B,C). This evidence concerns the gene FOXO1 and cancer.