In addition, PLX-R18 administration attenuated biomarkers of bone marrow aplasia, sepsis, and systemic inflammation and attenuated radiation-induced inflammatory cytokines/chemokines and growth factors, including G-CSF, MIP-1a, MIP-1b, IL-2, IL-6 and MCP-1, and modulate AKT protein expression. The gene discussed is CSF3; the disease is Sepsis.