We propose that regulation of Srm, Ryr-1, Eno3, Prkag3 and Eef1a2 genes involved in regulating arginine and proline metabolism, calcium signaling pathway, HIF-1 signaling pathway, oxytocin signaling pathway and legionellosis are may be involved in mechanisms by which MD-4 protects against gastric ulcers. The gene discussed is PRKAG3; the disease is gastric ulcer.