A study on JAK2V617F-positive myeloproliferative neoplasms revealed that HIF-1 signaling is involved in the regulation of genes promoting glycolysis (glucose transporters 1 and 3 (GLUT-1 and -3), phosphofructokinase/fructose-bisphosphatase 3 (PFKFB3), and lactate dehydrogenase A (LDHA)), while shunting pyruvate from TCA cycle (PDK1) [10]. Here, LDHA is linked to myeloproliferative neoplasm.