RHOT1 and cancer: We can understand how the existing mitochondria of cancer cells can potentially mediate mitochondria hijacking from normal cells by considering the following assumptions: (1) Upon tunneling nanotube formation, the interaction between mitochondrial Rho GTPase (Miro1) and actins—inside the nanotubes—mediates mitochondria migration from normal cells toward cancer cells; this process is GTP-dependent [2].