Significantly activated canonical pathways by TWEAK exposure predicted by IPA included integrin signaling, VEGF signaling, actin cytoskeleton signaling, ephrin receptor signaling, signaling by Rho family GTPases, regulation of actin-base motility by Rho, amyotrophic lateral sclerosis signaling, IL-8 signaling, RhoA signaling, Rac signaling, and NGF signaling. Here, AKT1 is linked to amyotrophic lateral sclerosis.