Acupuncture therapy is thought to have a positive impact on the treatment of PCOS through the following mechanisms: sympathetic output modulation through spinal reflexes [36]; modulation of hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes through the increase of β-endorphin secretion [37,38,39,40,41,42]; and influencing insulin sensitivity or resistance through functional balance of the insulin signaling pathways [43]. This evidence concerns the gene INS and polycystic ovary syndrome.