On the other hand, hormonal studies contemplated levels of FSH and LH, but no other important biomarkers that, in our opinion, would support better assessment of biochemical hyperandrogenism and hypothalamus–pituitary–gonad/adrenal (HPG/A) dysregulation, such as androstenedione, dehydroepiandrosterone and sex-hormone-binding globulin (SHBG). This evidence concerns the gene PLOD1 and hyperandrogenism.