Cheonwangbosim-dan (CV3), the herbal medicine to be administered for cognitive dysfunction in this study, has reportedly been effective for memory improvement in an Alzheimer’s disease mouse model by inhibiting acetylcholinesterase, reducing hippocampal infarction, and suppressing proinflammatory cytokine production such as IL-1β and TNF-α [25]. This evidence concerns the gene ACHE and Alzheimer disease.