Cheonwangbosim-dan (CV3), the herbal medicine to be administered for cognitive dysfunction in this study, has reportedly been effective for memory improvement in an Alzheimer’s disease mouse model by inhibiting acetylcholinesterase, reducing hippocampal infarction, and suppressing proinflammatory cytokine production such as IL-1β and TNF-α [25]. Here, TNF is linked to early-onset autosomal dominant Alzheimer disease.