COL4A2 and cirrhosis of liver: Additionally, COL4A2 expression was elevated not only in the liver tissues of preneoplastic and HCC compared to healthy controls [188], but also in the liver tissues of “HCV with HCC” compared to “HCV without HCC” patients [185], as well as in the serum samples of active chronic HCV infection with liver cirrhosis than cirrhosis-free controls [189].