Remarkably, this variant did not alter the ANGPTL4 effects on glucose metabolism as rs116843064*A was also observed to be significantly associated with lower serum FBG, better glucose tolerance following oral glucose tolerance test (OGTT), and improved insulin sensitivity, which was translated to 0.89-fold lower odds of T2DM [197]. The gene discussed is ANGPTL4; the disease is type 2 diabetes mellitus.