Overexpression of PDGFR-β in hypercholesterolemic mice with Apoe and Ldlr deficiency not only enhanced atherosclerosis via signal transducer and activator of transcription 1 (STAT-1) signaling, it also increased advanced plaques formation marked by plaque fibrosis and intraplaque hemorrhage [165]. The gene discussed is LDLR; the disease is atherosclerosis.