Perhaps, even if miR-29b-3p fails to silence COL6A3 mRNA transcript, translation of the mRNA harboring rs146092501*T variant would result in abnormal type VI collagen synthesis which is protective against vascular remodeling by promoting M1 to M2 macrophage polarization, since rs146092501*T was associated with a 0.16 times reduction in CHD risk, as seen in our meta-analysis (Table S2). The gene discussed is COL6A3; the disease is coronary artery disorder.