In the multivariate analysis, an old age > 65 years, anemia, albumin and CRP levels and infection with unidentified pathogens were significant factors contributing to low PWR levels (odds ratio (OR) 1.918; 95% confidence interval [17] 1.330–2.780; p < 0.001, OR 0.423; 95% CI 0.288–0.615; p < 0.001, OR 0.617; 95% CI 0.447–0.844; p < 0.001, OR 1.0005; 95% CI 0.999–1.002; p < 0.001, OR 0.545; 95% CI 0.334–0.833; p = 0.014, respectively). The gene discussed is CRP; the disease is infection.