Consistently, PFKFB4 is overexpressed in numerous malignancies, and its knockdown (with a molecular status comparable to haploinsufficiency) was demonstrated to inhibit proliferation and invasiveness in IHH-4 thyroid cancer cells alongside the upregulation of histone acetyltransferase GCN5 [37]. This evidence concerns the gene PFKFB4 and thyroid gland carcinoma.