In our analysis, CBX3/6/7 resulted in being the genes with the highest alteration rates in both RCC subtypes and their functions primarily related to the SUMOylation of DNA methylation proteins, chromatin organization proteins, RNA binding proteins, and signaling pathways that regulate pluripotency of stem cells, and transcriptional regulation by AKT, PTEN, and RUNX1 pathways. The gene discussed is PTEN; the disease is renal cell carcinoma.