Nevertheless, we observed that 70.8% of the somatotroph adenomas (n = 17/24) presented strong membranous expression of E-Cadherin (>50%) compared to 40% of corticotroph adenomas (n = 4/10), 42.8% of gonadotroph adenomas (n = 12/28) and 27.6% of null cell adenomas (n = 8/29). This evidence concerns the gene CDH1 and acromegaly.