Additionally, Cyclin-D1 was strongly expressed (expression > 50%) in 78.6% (n = 22/28) of the gonadotroph adenomas and in 65.5% (n = 19/29) of the null cell adenomas compared to only 20% of corticotroph (n = 2/10) and 20.8% of somatotroph (n = 5/24) adenomas. Here, CCND1 is linked to functioning gonadotropic adenoma.