Although, E-Cadherin expression has been already studied in patients with acromegaly and found that low expression has been associated with the worst response to somatostatin analogs [36], data on the possible association of PAs secretory profile with the expression of specific biomarkers such as Cyclin-D1 and E-Cadherin are rare and unclear [21,43,44,45]. The gene discussed is CCND1; the disease is gonorrhea.