The study indicated a positive correlation between several biochemical indicators (total bilirubin, ALT, AST, gamma-glutamyltranspeptidase (GGT), international normalized ratio (INR), GGT to platelet ratio (GPR), AST to platelet ratio, spleen size, pediatric end-stage liver disease score, and the existence of portal hypertension. The gene discussed is GGTLC1; the disease is portal hypertension.