In the case of CRSsNP, TLR2, TLR4, transforming growth factor β (TGFβ), and collagen are upregulated in comparison to CRSwNP and expression of TLR2 and TLR4 correlate with neutrophil infiltration [46]. The gene discussed is TGFB1; the disease is chronic rhinosinusitis with nasal polyps.