The role of CAND1 in regulating the androgen receptor has been studied in prostate cancer, in which CAND1 has been shown to mediate cancer aggressiveness, possibly not through the androgen receptor signaling pathway, as it was shown to mediate cancer aggressiveness in androgen receptor-positive and -negative prostate cancer cell lines [15]. The gene discussed is CAND1; the disease is Familial prostate cancer.