CAND1 and breast carcinoma: Moreover, combining bioinformatics with computer-aided diagnosis techniques, including cloud-based extreme learning machine, intuitionistic fuzzy active contour method, and neutosophic set-based medical image analysis, is crucial to validate our observations and to further explore the prognostic value of CAND1 in Erα-positive breast cancer, as these techniques outperform other techniques in diagnosing cancers and predicting outcomes [50,51,52].