Nevertheless, because patients with Phenotype A and B compared to Phenotype C and Phenotype D have higher mean body weight, insulin levels, and insulin resistance and more altered lipid pattern [10,11], it has been suggested that the Rotterdam classification may indeed include differences in insulin resistance and lipid pattern due to the majority of patients with Phenotype A or B being obese with metabolic alterations and more severe insulin resistance while most patients with Phenotype C lean with mild insulin resistance and no altered lipid profile [3,4,5,11]. This evidence concerns the gene INS and Insulin resistance.