IL13 and chronic rhinosinusitis with nasal polyps: In CRSwNP, sinonasal tissue displays significantly higher levels of eosinophilic markers and Th2 polarization with high IL-5, IL-13, and IgE concentrations, whereas CRSsNP is characterized by a Th1 polarization with high levels of IFN-γ and TGF-β [12].