In contrast to the high AUROC of YKL-40 in assessing the stage of hepatic fibrosis in HCV patients without kidney failures, Schiavon et al. showed that the AUROC of YKL-40 in predicting a fibrosis stage of ≥F2 in hemodialysis patients with HCV infection was only 0.607 [51]. The gene discussed is CHI3L1; the disease is kidney failure.