EV activity is expressed by ADC binding to the cells which express nectin-4, to whom follows ADC-nectin-4 complex internalization and MMAE release due to a proteolytic cleavage, which damages microtubules system in the target cell, causing the blockage of the cycle cell and the cytotoxic cell death of the tumor cell by apoptosis. The gene discussed is NECTIN4; the disease is neoplasm.