The LoVo colorectal cancer cells overexpress miR-1273g-3p, which directly targets CNR1 [110], leading to activation of the Erb-B2 receptor tyrosine kinase 4 (ERBB4)/phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3)/mechanistic target of rapamycin (mTOR)/S6 kinase 2 (S6K2) pathway, eventually promoting the malignant behavior of LoVo cells. This evidence concerns the gene PIK3R3 and colorectal cancer.