MGLL and neoplasm: Functional studies have shown that inhibition or knockdown of MAGL significantly suppresses proliferation, migration, invasion, and xenograft tumor growth in vitro and/or in vivo [54,134,136,137,138]; knockdown of MAGL also induces apoptosis and cell cycle arrest via downregulation of cyclin D1 and Bcl-2 [54,137], or upregulation of Bax and cleaved caspase-3 [136].