Pharmacological activation of CB1R and CB2R induces apoptosis of hepatocellular carcinoma cells through upregulation of proapoptotic factors Bax and Bcl-x(s) and downregulation of antiapoptotic factors Bcl-2 and survivin, through activation of JNK/p38 MAPK pathway [166]. Here, CNR1 is linked to hepatocellular carcinoma.