TNFSF10 and leukemia: Additionally, LUV-TRAIL was also efficient against rhTRAIL-resistant leukemia cells [143], likely due to the arrangement of TRAIL into highly ordered oligomers on the LUVs which could induce a high level of DR4/DR5 clustering on the leukemic cells leading to increased pro-caspase-8 activation able to drive a type I extrinsic cell death pathway [129,187].