In a recent report, Gram-negative bEVs derived from a genetically modified, endotoxin-free Escherichia coli (E. coli) strain showed selective tropism for tumor tissues when administered systematically, and induced lasting anti-tumor immune responses through the production of cytokines CXCL10 and interferon-γ, with no adverse reactions [97]. This evidence concerns the gene CXCL10 and neoplasm.