SNAI2 and neoplasm: Additionally, using MCF10A breast cancer cells, Zhou et al. demonstrated that SIRT2 promotes the growth and aggressiveness of basal-like breast cancer by deacetylating the K116 domain of slug [61], a tumor promoter protein that, upon stabilization, facilitates tumor progression and metastasis through EMT, leading to loss of cell adhesion, as well as the enhancement of migratory and invasive properties of tumors [138].