PRDX1 and breast cancer: To further support the tumor-suppressing role of SIRT2 in breast cancer, Fiskus et al. demonstrated that SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 (an antioxidant), thereby sensitizing MCF-7 and MDA-MB-231 breast cancer cells to the cytotoxic effects of increased reactive oxygen species and DNA damage [60].