FOXO3 and Familial prostate cancer: Corroborating this finding, Li et al. found that SIRT3 expression suppressed EMT (via upregulation of E-cadherin and downregulation of N-cadherin and vimentin expression) in C42B prostate cancer cells by upregulating FOXO3A [93], a transcription factor that has been shown to suppress EMT and metastasis of prostate cancer [169].