Additionally, SIRT1 can promote the migration and invasion of PC3 prostate cancer cells by antagonizing p300/CBP-associated protein (PCAF)-catalyzed MPP8-K439 acetylation, thereby preventing ubiquitin-proteasome-mediated proteolysis of M-phase phosphoprotein 8 [88], a methyl-H3K9 binding protein that promotes E-cadherin gene silencing and EMT of tumor cells. Here, MPHOSPH8 is linked to Familial prostate cancer.