SIRT1 and prostate cancer: For instance, by inhibiting SIRT1 protein expression, researchers demonstrated that miR-449a ectopic expression suppresses the invasiveness of prostate cancer [217]; miR-204 enhances both docetaxel-induced apoptosis [214] and doxorubicin-induced mitochondrial-mediated apoptosis [216] of prostate cancer, and miR-138-5p inhibits the proliferation and lipid metabolism of prostate cancer [215].