SIRT7 and prostate carcinoma: Similarly, corroborating the above-mentioned findings, Haider et al. demonstrated that SIRT7-knockdown reduced the migration of DU145 prostate cancer cells and that SIRT7 overexpression promoted the aggressiveness and docetaxel resistance of LNCaP prostate cancer cells by triggering EMT as demonstrated by an increase in fibronectin [105].