VIM and Familial prostate cancer: Similarly, Cui et al. [84] showed that siRNA-mediated silencing of SIRT1 expression suppressed the migration and invasion of PC3 prostate cancer cells by upregulating E-cadherin and downregulating N-cadherin and vimentin expression, thus suggesting that SIRT1 activates EMT to promote the migration and metastasis of prostate cancer.