NPAS2 and posterior cortical atrophy: Epidemiological evidence suggests that the circadian pathway is significantly associated with advanced PCa among night shift workers, particularly those who worked for at least 20 years and had long shifts; at the gene level, the night shift workers exhibited altered BMAL1, NPAS2, and RORA, which is associated with aggressive PCa, yet there were not significant associations found at the SNP-level [24].