CD274 and osteosarcoma: Huang and colleagues reported the successful construction of an anti-human PD-L1 antibody with iodine-124 labeling for noninvasive detection of PD-L1 expression in an osteosarcoma mouse model (human OS-732 cells were inoculated); therefore, this study lays the foundation for further investigations regarding noninvasive osteosarcoma diagnostics and targeted therapy in patients with high levels of PD-L1 receptor expression [75].