Karkare et al. presented their results regarding targeting insulin growth factor receptor type 2 (IGF2R) by microSPECT/CT imaging in osteosarcoma patient-derived xenografts (PDX) in mouse models and in canine osteosarcoma tumors, which showed selective uptake of the radiolabeled IGF2R-specific antibody. The gene discussed is IGF2R; the disease is osteosarcoma.