Within the tumor, MDSCs were completely eliminated by the modified NK cells in vivo: this was associated with an increase in intratumoral proinflammatory cytokines, which led to higher recruitment and infiltration of CAR T cells within TME, providing stronger tumor regression in NKG2D.ζ-NK/anti-GD2 CAR T-cell-treated mice with respect to the control group only treated with anti-GD2 CAR T cells [89]. This evidence concerns the gene KLRK1 and neoplasm.