CEACAM5 and neoplasm: In the case of liver metastases of mouse epithelial colon carcinoma expressing carcinoembryonic antigen (CEA), it has been shown that tumor cells are sensitive to anti-CEA CAR T cells, whose efficacy is in turn influenced by high intrahepatic levels of myeloid-derived suppressive cells (MDSCs) belonging to hostile TME, and able to dramatically quench CAR T activity [58].