IL4 and cancer: Interestingly, IL-4-induced M2-like macrophages phagocytosed more nanoparticles compared to PBS-treated M0 macrophages in both HA modified iron oxide nanoparticles and dual-modified HA-man@Fe3O4 (Figure 2C), which further satisfied the need of repolarizing TAMs that have been educated by cancer cells for a long time and turned M2-like.