KLK3 and posterior cortical atrophy: After the stated position of the US Preventive Services Task Force against PCa screening with prostate-specific antigen (PSA), due to the high percentage of unnecessary prostate biopsies and overdetection of insignificant PCa (iPCa) [2], early detection of PCa has evolved towards csPCa due to the spread of pre-biopsy multiparametric magnetic resonance imaging (mpMRI) [3].