KLK3 and posterior cortical atrophy: Recently, the initial PCa suspicion of 2881 men has been stratified to avoid MRI scans first from the subset of men with serum PSA > 10 ng/mL and abnormal DRE [43], and thereafter with the PSA density calculated from the prostate volume estimated with DRE, resulting in a 20.3% reduction of MRI scans with 3.8% missing csPCa [21].