Furthermore, the depletion of CEMIP in prostate cancer cells reduces the expression of pyruvate dehydrogenase kinase isoform 4 (PDK4) and lactate dehydrogenase A (LDHA), enzymes important for efficient glycolysis in tumor cells, thereby decreasing cellular pyruvate, lactate, and ATP levels. The gene discussed is LDHA; the disease is Familial prostate cancer.