CEMIP and pancreatic neoplasm: CEMIP has been demonstrated to foster the depolymerization of HMW-HA into low- and intermediate-sized HA oligosaccharides (LMW/IMW-HA) [3,89,90] and the enhanced expression of CEMIP in pancreatic tumor cells leads to increased levels of HA oligosaccharides, which is associated with increased invasive behavior [91].