The perpetuation of a non-resolving inflammatory response is characterized by immune cell infiltration, mainly tumor-associated macrophages, immature myeloid cells and T cells, by the dysregulated production of cytokines with the balance leaning towards pro- (TNF-α, IL-6, IL-1) rather than anti-inflammatory cytokine (IL-10, IL-12, TGFβ) production and by the occurrence of angiogenesis and tissue remodeling that favors the sequence fibrosis-cirrhosis-HCC [101]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.