The dysregulation of the circadian clock function in different human cancers is closely associated with a constitutive activation of intracellular inflammatory and oncogenic signaling pathways including p38, c-Myc, NF-κB, BCL-XL, PKA, aberrant chromatic remodeling, deregulation of inflammatory cytokines and suppression of tumor suppressors ATM, p53 and p21 [132]. This evidence concerns the gene CLOCK and cancer.