AKT1 and hyperinsulinism: Therefore, hyperinsulinemia increases the risk of liver cancer as it favors cell proliferation and inhibits apoptosis and also as it activates phosphatidylinositol 3-kinase (P13K)/protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) by binding to the insulin receptor substrate (IRS) [46,47].