In turn, miR-802-5p downregulates heat shock protein 60 (HSP60), upregulates CCAAT/enhancer binding protein (C/EBP) homologs, and enhances oxidative stress and phosphorylation of c Jun NH(2) terminal kinase (JNK) and insulin receptor substrate 1 (IRS1), leading to the development of insulin resistance [128]. Here, IRS1 is linked to Insulin resistance.