MCM4 and metastatic malignant neoplasm in the lymph nodes: The multivariate Cox regression analysis of MCM4 indicated that tumor size (HR = 1.550, p = 0.012), lymph node metastasis (HR = 1.974, p < 0.0001) and high expression of MCM4 (HR = 1.459, p = 0.019) were closely related to OS in LUAD patients (Table 3).