CEA and CA199 provided an accurate prediction of intrapulmonary and distant metastasis with the AUC of 0.69 both (p < 0.001); CEA, CYFRA 21-1 and CA199 provided an accurate prediction of lymphatic metastasis with the AUC of 0.62 (p < 0.001). The gene discussed is CEACAM5; the disease is Lymphatic Metastasis.