The results showed that the levels of SCC-Ag, ProGRP and CA199 in patients with lymphatic metastasis, and the levels of CEA, CYFRA 21-1 and NSE in patients with intrapulmonary, lymphatic, and distant metastasis, were significantly higher than those patients with non-metastasis. The gene discussed is CEACAM5; the disease is Lymphatic Metastasis.