Our analysis of differentially methylated genes by comparing RMCs with other kidney tumors predominantly revealed genes of early nephrogenesis to be hypomethylated in RMCs: EYA1, for instance, a transcription factor that has been shown to be a key initiator of MM development [36], is hypomethylated compared to KIPR and KIRCs. The gene discussed is EYA1; the disease is Miyoshi myopathy.