Only four of the 27 analyzed genes related to kidney development were significantly differentially methylated in Wilms tumors; CDH1 is hypomethylated in Wilms tumors (mean = 0.357) compared to RMCs (mean = 0.559, p = 0.039) as well as KDR (p = 0.028), FGFR2 (p = 0.007), while GATA3 (mean = 0.74) is hypermethylated compared to RMCs (mean = 0.566, p = 0.0005) (Figure S4). Here, KDR is linked to Wilms tumor.