The up-regulated mitochondrial NADK2 kinase is tumor-promoting [54] and is up-regulated in the knockout cells alongside with further proteins associated to mitochondrial function (HEL-S-26/IDH1, HEL-S-95n/SORD, ABAT, ACADSB, TIGAR/C12orf5, ACSL1, NAPG; see Figure 8 and accompanying text). This evidence concerns the gene IDH1 and neoplasm.