Multiple co-mutation events were identified in the GI group at a high frequency, such as TP53/EGFR, TP53/RB1, TP53/ERBB2, and TP53/KMT2C (Figure 6F–I, p < 0.05), and a higher GI score was detected in MM patients with the co-mutation of either TP53/EGFR, TP53/RB1, TP53/ERBB2, or TP53/KMT2C (Figure 6J–K, p < 0.001), suggesting a close correlation between these co-mutations and a high GI status in MM. This evidence concerns the gene RB1 and Miyoshi myopathy.