Immune evasion is a common trait of Hodgkin lymphoma (HL), and beyond the aforementioned cytokine-mediated pathway, there are two more characteristics of HL pathogenesis that result in overexpression of PD-L1 and PD-L2: overactive JAK-STAT signaling pathway (Janus kinases and signal transducers and activators of transcription; together with the constitutive NF-κB activation) and amplification or gains of chromosome 9p24.1, where their genetic loci reside [82]. Here, CD274 is linked to Hodgkins lymphoma.