Several inhibitory immunoreceptors, including but not limited to PD-1, CTLA-4, T cell immunoglobulin, and mucin domain containing-3 (TIM3), lymphocyte-activation gene 3 (LAG3), and T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), have been identified and characterized in cancer [36,37,38]. The gene discussed is LAG3; the disease is cancer.