MITF and melanoma: In order to make certain that the redox-mediated phenomena we observed in Figure 4 were not restricted to the engineered PIG1 cells, we performed the same analysis in the parent cell line, in M14 melanoma cells, in M14 melanoma cells transfected with HA-FLAG-tagged MITF, and in M14 cells in which one allele of the gene encoding TR1 (TXNRD1) was disrupted using CRISPR/Cas9.