Genetic risk factors include family history, light skin/hair/eye color, DNA repair defects, and several melanoma risk genes, such as cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A), CDK4, BRCA1-associated protein-1 (BAP1), protection of telomeres 1 (POT1), and telomerase reverse transcriptase (TERT) [15,16]. The gene discussed is TERT; the disease is melanoma.