Venkatesh and colleagues of the Monje lab explained a mechanism of how neuronal activity promotes high-grade gliomal growth, showing that the upregulation of neuroligin-3 (NLGN3) in postsynaptic neurons promotes the proliferation of gliomal tumor cells through the induction of PI3K-mTOR signaling [118]. This evidence concerns the gene NLGN3 and neoplasm.