Thus, in the present study, we studied somatic alterations at the DNA, mRNA, and miRNA level in ESCC to investigate the relation of DNA somatic changes to expression of mRNA and target miRNAs in CSMD1 to help us better understand the role of SNPs in non-coding regions with somatic alterations in expression in this ESCC tumor gene. This evidence concerns the gene CSMD1 and neoplasm.